Results
| PMID | 24889313 |
| Gene Name | HP |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 30 |
| Population details | 30 (15 patients with endometriosis, 15 patients without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Mol Med Rep. 2014 Aug;10(2):725-30. doi: 10.3892/mmr.2014.2291. Epub 2014 May 30. Hwang, Jin-Hee| Lee, Kyu-Sup| Joo, Jong-Kil| Wang, Tao| Son, Jung-Bin| Park, Jong-Ha| Hwang, Dae-Youn| Choi, Man-Ho| Lee, Hong-Gu Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143701, South Korea.| Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis. Mesh Terms: Adult| Animals| Biomarkers/*blood| Disease Models, Animal| Down-Regulation| Electrophoresis, Gel, Two-Dimensional| Endometriosis/diagnosis/etiology/*metabolism| Female| Haptoglobins/metabolism| Humans| Mice| Mice, Inbred BALB C| *Proteomics| |
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